Trichloromonofluoromethane Click to View Image CCl3F 137.37
Methane,trichlorofluoro-.
Trichlorofluoromethane [75-69-4]. »Trichloromonofluoromethane contains not less than 99.6percent and not more than 100.0percent of CCl3F,calculated on the anhydrous basis. Packaging and storage— Preserve in tight cylinders,and avoid exposure to excessive heat. Identification— The IRabsorption spectrum of it,determined in a 10-cm cell with sodium chloride windows,at atmospheric pressure,exhibits maxima,among others,at the following wavelengths,in µm:4.67(m),5.95(m),7.28(s),8.06(m),9.2(vs),10.7(vs),11.8(vs),and 13.4(m).The stronger maxima are best obtained at pressures less than 10mm of mercury. Boiling temperature: approximately 24,determined as directed under Approximate Boiling Temperature(see Aerosols,Nasal Sprays,Metered-Dose Inhalers,and Dry Powder Inhalers á601ñ). Water: not more than 0.001%,determined as directed under Water Content(see Aerosols,Nasal Sprays,Metered-Dose Inhalers,and Dry Powder Inhalers á601ñand Method Icunder Water Determination á921ñ). High-boiling residues: not more than 0.01%,determined as directed for High-Boiling Residues,Method I,under Aerosols,Nasal Sprays,Metered-Dose Inhalers,and Dry Powder Inhalers á601ñ. Chromatographic purity— In the chromatogram recorded for the Assay,identify the peaks due to dichlorodifluoromethane and dichlorotetrafluoroethane from relative retention times observed on chromatographing the Resolution preparation:the sum of these two peak areas is not greater than 0.2%of the total of all peak areas;and the sum of the areas of all peaks other than that for trichloromonofluoromethane is not greater than 0.4%of the total of all peak areas. Inorganic chlorides— Place 5mLof anhydrous methanol in a test tube,add 3drops of a saturated solution of silver nitrate in anhydrous methanol,shake,and add 7g of Trichloromonofluoromethane:no opalescence or turbidity is produced. Assay— Resolution preparation and Chromatographic system—Proceed as directed in the Assayunder Dichlorodifluoromethane. Assay preparation— Introduce the liquid phase of Trichloromonofluoromethane into an evacuated headspace vial. Procedure— Inject the gas phase headspace Assay preparationinto the chromatograph,record the chromatogram,and measure the peak areas.Calculate the percentage (a/a)of CCl3Fin the portion of Trichloromonofluoromethane taken. Auxiliary Information— Staff Liaison:Karen A Russo,Ph.D.,Scientist Expert Committee:(PA1)Pharmaceutical Analysis 1 USP28–NF23Page 3100 Pharmacopeial Forum:Volume No.27(1)Page 1825 Phone Number:1-301-816-8379