Tropicamide Click to View Image C17H20N2O2 284.35
(±)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide [1508-75-4]. »Tropicamide contains not less than 99.0percent and not more than 101.0percent of C17H20N2O2,calculated on the dried basis. Packaging and storage— Preserve in tight,light-resistant containers. USP Reference standards á11ñ USP Tropicamide RS. Identification— A: Infrared Absorption á197Kñ. B: Ultraviolet Absorption á197UñSolution: 25µg per mL. Medium: 3Nhydrochloric acid. Melting range,Class Iá741ñ: between 96and 100. Loss on drying á731ñ Dry about 500mg,accurately weighed,in vacuum over phosphorus pentoxide at 80for 4hours:it loses not more than 0.5%of its weight. Heavy metals,Method IIá231ñ: 0.002%. Assay— Dissolve about 750mg of Tropicamide,accurately weighed,in 80mLof glacial acetic acid,add 4drops of crystal violet TS,and titrate with 0.1Nperchloric acid VSto a blue-green endpoint.Perform a blank determination,and make any necessary correction.Each mLof 0.1Nperchloric acid is equivalent to 28.44mg of C17H20N2O2. Auxiliary Information— Staff Liaison:Lawrence Evans,III,Ph.D.,Scientist Expert Committee:(PA6)Pharmaceutical Analysis 6 USP28–NF23Page 1998 Phone Number:1-301-816-8389