Triacetin Click to View Image C9H14O6 218.21
1,2,3-Propanetriol triacetate.
Triacetin.
Glyceryl triacetate [102-76-1]. »Triacetin contains not less than 97.0percent and not more than 100.5percent of C9H14O6,calculated on the anhydrous basis. Packaging and storage— Preserve in tight containers. USP Reference standards á11ñ USP Triacetin RS. Identification— A: Infrared Absorption á197Fñ. B: The solution prepared as directed in the Assayresponds to the tests for Acetate á191ñ. Specific gravity á841ñ: not less than 1.152and not more than 1.158. Refractive index á831ñ: not less than 1.429and not more than 1.430. Acidity— Dilute 25g of Triacetin,accurately weighed,with 50mLof neutralized alcohol,add 5drops of phenolphthalein TS,and titrate with 0.020Nsodium hydroxide:not more than 1.0mLof 0.020Nsodium hydroxide is required for neutralization. Water,Method Iá921ñ: not more than 0.2%is found. Assay— Transfer about 1g of Triacetin,accurately weighed,to a 250-mLboiling flask,add 50.0mLof 0.5Nalcoholic potassium hydroxide VS,connect the flask to a water-jacketed condenser,and reflux on a steam bath for 45minutes,swirling frequently.Cool,add 5drops of phenolphthalein TS,and titrate the excess alkali with 0.5Nhydrochloric acid VS.Perform a blank determination (see Residual Titrationsunder Titrimetry á541ñ).Each mLof 0.5Nalcoholic potassium hydroxide is equivalent to 36.37mg of C9H14O6. Auxiliary Information— Staff Liaison:Behnam Davani,Ph.D.,MBA,Senior Scientist Expert Committee:(PA7)Pharmaceutical Analysis 7 USP28–NF23Page 1957 Phone Number:1-301-816-8394